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AGING, REJUVENATION AND STEM CELLS

We all want to live longer more productive more active lives without losing our capabilities or vitality. Stem cell research in this area is still evolving and there is still so much to be learned and understood before it can be applied. However if you want to do something today then click on the "Amazing Stem Cell Discovery link" on the right hand side of this page

ARTICLES

Stem cells, ageing and the quest for immortality

Thomas A. Rando Nature 441, 1080-1086 (29 June 2006) Published online 28 June 2006

Listen to an interview with Tom Rando on the stem cells podcast

Adult stem cells reside in most mammalian tissues, but the extent to which they contribute to normal homeostasis and repair varies widely. There is an overall decline in tissue regenerative potential with age, and the question arises as to whether this is due to the intrinsic ageing of stem cells or, rather, to the impairment of stem-cell function in the aged tissue environment. Unravelling these distinct contributions to the aged phenotype will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.

The role of stem cells in aging

Experimental Hematology, Volume 31, Issue 8, Pages 659-672

... Those parts of the world enjoying an ever-increasing standard of living are also inhabited by an increasingly elderly population. The effects of age on many physiological functions are not well studied or appreciated. A public health challenge to provide increased quality of life for this growing segment of the population requires more attention to the variable of age in experimental studies. Stem cell populations are likely to be a fruitful subject for studies of this type.

Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity

G de Haan, W Nijhof and G Van Zant

University of Kentucky Medical Center, Division of Hematology/Oncology, Markey Cancer Center, Lexington 40536-0093, USA.

Amongst other things this report states...when absolute frequencies were calculated, there was a trend for longer lifespan to be correlated with a larger stem cell pool.

The regenerative potential of stem cell therapeutics in the anti-aging setting

Townsend Letter for Doctors and Patients, Dec, 2005 by Robert Goldman, Ronald Klatz

Science now stands on the threshold of a new age in cellular therapy and tissue regeneration which will directly and beneficially impact how long, and how well, we will live in the coming decades. Stem cell therapeutics is the leading biomedical technology in the rapidly emerging field of regenerative medicine, a medical field in which science assists the human capacity to heal various tissues and organs. All of the most impressive demonstrations of regenerative medicine, since its

Stem cell therapy as a therapeutic intervention for aging is rooted in 30 years of research and clinical application. Stem cell therapeutics have been successfully utilized around the world to treat a wide range of aging-related disorders including heart disease, diabetes, stroke, cancer, obesity, arthritis, Parkinson's disease, and other infirmities associated with aging metabolism.nception in 2002, have used stem cells to trigger healing in the patient.

As we age, our stem cell reserves with which we are born, decline. Our cells diminish in their ability to regenerate and repair tissue..... Read the full article here

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