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STEM CELLS AND RECOVERY FROM INJURY

Transplantation of Bone Marrow Stem Cells as well as Mobilisation by Granulocyte-Colony Stimulating Factor Promotes Recovery after Spinal Cord Injury in Rats

Lucia Urdzíková, Pavla Jendelová, KateYina Glogarová, Martin Burian, Milan Hájek, Eva Syková. Journal of Neurotrauma. September 2006, 23(9): 1379-1391. doi:10.1089/neu.2006.23.1379. Published in Volume: 23 Issue 9: September 7, 2006

...We conclude that treatment with three different bone marrow cell populations had a positive effect on behavioural outcome and histopathological assessment after SCI, which was most pronounced after MSC injection.

Harnessing the stem cell for the treatment of tendon injuries: heralding a new dawn?

R K W Smith, P M Webbon British Journal of Sports Medicine 2005;39:582-584

Stem cell technology may be useful in the treatment of tendon and ligament injuries

Strain induced tendon or ligament injuries are an all too common consequence of athletic endeavour in both horses and humans, resulting in high morbidity and often compromising a return to the same level of activity.

Application of Mesenchymal Stem Cells in the Regeneration of Musculoskeletal Tissues

Edward J. Caterson, BS, Leon J. Nesti, PhD, Todd Albert, MD, Keith Danielson, PhD, Rocky Tuan, PhD, Department of Orthopaedic Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania Published: 02/05/2001 source: Medscape

...Clinically applicable techniques to isolate, expand, and re-implant these autogenous cells will become part of the repertoire of orthopaedic therapy. In the presence of extrinsic signalling molecules, provided by both the clinician and the local cellular environment, the intrinsic multipotential nature of the stem cells may be realised for applications such as the replacement of bone graft for segmental defects, nonunions, and spinal fusions. Additional applications may include treatment of full-thickness articular defects and articular resurfacing by site-specific delivery of stem cells. The ultimate goal is directed cellular regeneration of damaged or diseased musculoskeletal tissue. Currently, the limitation is our knowledge and ability to direct this differentiation, but with further study molecular orthopaedic interventions should become a reality.

Role of a mixed type, moderate intensity exercise programme after peripheral blood stem cell transplantation

S C Hayes, P S Davies, T W Parker, J Bashford, A Green British Journal of Sports Medicine 2004;38:304-309

Objectives: To evaluate the effect of peripheral blood stem cell transplantation on functional capacity, and to determine the role of a mixed type, moderate intensity exercise programme in the recovery of patients after intensive cancer treatment.

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