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Why Adult Stem Cells? References

26 Willing AE et al., “Mobilized peripheral blood stem cells administered intravenously produce functional recovery in stroke”, Cell Transplantation 12, 449-454; 2003; Arvidsson A et al.; “Neuronal replacement from endogenous precursors in the adult brain after stroke; Nature Medicine 8, 963-970; Sept 2002; Riess P et al.; “Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury”; Neurosurgery 51, 1043- 1052; Oct 2002

27 Hofstetter CP et al., “Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery”, Proc Natl Acad Sci USA 99, 2199-2204; 19 February 2002; Sasaki M et al., "Transplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axons," Glia 35, 26-34; July 2001; Ramón-Cueto A et al., "Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia," Neuron 25, 425- 435; February 2000

28 Liker MA et al.; “Human neural stem cell transplantation in the MPTP-lesioned mouse”; Brain Research 971, 168-177; May 2003; Ĺkerud P et al.; “Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson’s disease”; Molecular and Cellular Neuroscience 21, 205- 222; Nov 2002; Ourednik J et al.; Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons; Nature Biotechnology 20, 1103-1110; Nov 2002

29 Otani A et al., “Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells”, J. Clinical Investigation 114, 765-774, September 2004; Otani A et al., “Bone marrow derived stem cells target retinal astrocytes and can promotes or inhibit retinal angiogenesis”; Nature Medicine 8, 1004-1010; Sept 2002; Tomita M et al., “Bone marrow derived stem cells can differentiate into retinal cells in injured rat retina”; Stem Cells 20, 279-283; 2002

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